Season 5, Episode 8: Ch-Ch-Changes

Grissom shows his sensitive side in his talks with Wendy's friend Mimosa, who is also a transgendered woman. He's not put off by her subtle flirting, perhaps because in a way, he relates to her. Grissom is an outsider, too—not as much of one as a transgendered person in society, but nonetheless, quiet, awkward Grissom doesn't feel like he fits in with most people either.

His scenes with Mimosa, both in the bar and in his office after the case is solved are both subtle and moving. William Petersen conveys compassion and sympathy especially well in the scene where he has to tell Mimosa that Wendy was killed by someone in the transgender community, a blow Mimosa takes especially hard.